I just encountered malware on my sister's laptop not long ago. It has Vista 64-bit. When I let it load, then I can't use new applications, because I get a pop-up saying that (filename) cannot be executed. (for every .exe file I try to run) Does this sound familiar? And if I open Task Manager early, I can kill the malware process. The process name looked suspicious, had random characters. Then System Restore worked and I was able to get it restored to a date in 2010.