Yes, I am already aware of One-Core-API, and while it is indeed awesome as mentioned by @FranceBB, I still think it needs more development, because there does still exist some issues, as you said. I am grateful for the fact that it runs very modern programs, but unfortunately, it breaks already working programs that don't need One-Core-API to work, for example, Supermium. I discovered this recently.
Yes, the uninstaller works.