nLite does not really slipstream hotfixes; all nLite does is chain installing them via SVCPACK. So the more hotfixes you "slipstream" with nLite, the larger your installation media will become. That said, why not use an update pack, like Xable's, RedXII's, RyanVM's/User_Hidden's or Onepiece? These packs are really slipstreamed into your installation media, overwriting old files and such.