One thing that I do after the mobo is in is to use the antistatic sheets that either a mobo,modem,vid card came with.I use these to rest each add in card on for antistatic and anti abrasive protection.Do wear an antistatic wrist band as Drew said.I haven't cooked anything yet by this procedure.Use masking tape to label each startup lead wire(reset,led,power,etc).Easier to read that way.Make sure the arrow or #1 on each lead goes to the #1 pin on the board or corresponding connection.Likewise on all connections(FD,IDE,fans).You should take the CPU and memory off in addition to all your cards.Take notes,draw pictures,and take your time.Read your documentation in the mobo manual.If you don't have one go on line and download the file and print it out.Read Tinker's suggested "How to build a PC" site.Sound like alot? To most of us that have we can do these things a bit easier after researching and doing.Have fun.