Windows Defender is the second thing I always disable when I reinstall or upgrade. UAC being the first.
Telling me non malicious software is bad. *%("@ you windows!
All I have for protection is;
custom hosts file, clamwin av portable, spybot portable, spyware blaster portable, loads of services disabled, 99% tasks disabled, firefox w/ ublock and few other addons and a large tweaked prefs file, w10privacy, blackbird, o&o shutup10, lots of reg tweaks, custom firewall rules and common sense.
I don't let windows control anything that I can do myself.