I just checked Dosbox-X, seems nice. Maybe a bit overloaded with options for you though.
Configuration Tool > Mixer
Increase buffersize and prebuffer (0-100%). This may make sound be delayed a bit.
Reduce the sampling rate in the sound mixer, and also in the emulated sound card settings (SB, GUS, etc.). Use standard values like 22050 or 11025. This will lower the sound quality a bit though,
Also try to free some CPU from other parts of the emulation - disable unused hardware like network, floppy, IDE ports, etc.
Enable Frameskip - this is a compromise between speed (with "jumpy" video) and smooth video (but slowed down if host CPU can't keep up).
Disable video scaler and V-Sync.
Try Dynamic CPU core.
Reduce emulated CPU speed/cycles.
If nothing helps, try the regular Dosbox with the frontend from my first post. It has a database with settings for many games.