Recommendation: When you should consider disabling Superfetch: - systems with low RAM and no ReadyBoost available - laptops (lots of disk I/O generates so much heat, and the disk are very noisy & slow) - virtual machines (lots of physical disk I/O to the .vhd file, chance of double-caching) - temporarily on systems I am going to be rebooting a lot (e.g. hotfixes on a clean installation, installation of kernel drivers requiring reboots, etc.)