In general, Vista extended kernel works very well for me in version 20230306. However, I will share my solutions to run software that with the extended kernel does not work properly and some other things.
Vegas Pro 18 (and older versions) - For some reason, Vegas Pro 18 as well as older versions such as 16 or 14 did not want to run properly when I used any of the extended kernel versions, latest or older redirected locally. The solution turned out to be a local redirect of the original kernel32.dll, but that's not the end of the story. You have to replace one of the kernel32 imports in the Vegas ErrorReport.dll file using CFF Explorer (I don't remember the exact name, but it is the only import with the beginning of the name K32). The second missing function TryAcquireSRWLockExclusive should be added to the exports using ExportTableTester and CFF Explorer in the original kernel32 redirected locally.
MegaDownloader 1.8 - here it was enough to redirect locally kernel32.dll from the October version of the extended kernel.
Zoom - to run it, just redirect gdiplus.dll locally from Windows 7.
Chromium-based browsers - the March 6 version messed up the video in these browsers, the solution is to install the new March 9 version with the corrected userenv.dll and kernel32.dll file.
I also tried to install Office 2013 according to one user's guide, none of the programs wanted to run, I have no idea what caused it, because I installed the good old Office 2010 anyway
As for Discord, the unofficial Lightcord client works seamlessly. Be aware, however, that Discord can ban user accounts for using unofficial clients. Win32 mentioned that the failure of the official Discord client to work may be due to IE dependencies. But that would be illogical, since the same client works on Windows 7 with IE8 installed.
.NET 4.8 was unfortunately problematic, version 4.6.2 is enough for 95% of the software, and it does not cause problems with application performance.