Both AGP and PCI-E cards are supported. I built a new pc with Opteron 154. X850XT, Audigy2, and GA-K8A480M-9(ATI RS480 + Uli M1573), it is surprising that X850XT works without major problem. X800pro AGP works with older CATALYST, but it is necessary to install CATALYST 6.2 for X850XT PCI-E before downgrading driver. However, Uli M1573 does not support SATA, because Uli didn't complete win98/me driver for M1573 (M5287 SATA Controller). Besides, all USB devices(floppy, flash disk) disappear after installing Uli USB 2.0 driver. Switching to Orangeware driver and USB 2.0 devices disappear, so finally I gave up