Is there any real difference, other than disk space, between a vLited Vista install and a tweaked Vista install (disabled services and all that stuff)?

I find no difference between nLited XP and tweaked XP (mostly just disabling services). It would be something to try, but, Vista has so much crap running by default it's a ton more work to tweak Vista than XP, vLite saves a lot of time for me..

Tweaked Vista is much Better as there is no complications in installing service pack,updates or other applications but in vlited vista u might face problem like that component missing etc. Also tweaked vista is more stable than vlited vista.

you can always tweak vlited vista (i assumed everybody do it )

if you worry about compatibility issues just stay away from System and Services components

With vLite you can save space on your HD.

Never had problems with my vlited vista, I hope that nuhi will release a new version when service pack 2 will come!