You can't boot after you boot. It simply can not be done. The boot loader is designed to only read from one device. About the closest thing you could do is to have the DOS level USB drivers load, then call the USB CD-ROM, and do the same type of things you would do in the boot scenario. There has to be a floppy drive in this scenario, so I would advocate using this to boot, load the USB drivers (if available) then launch Ghost, Drive Image, or whatever tool you want to use from the CD. It can be setup to where when the .CMD file launches, all the rest is hands-off. This way, all you have to do is plug in the drive, pop in the floppy, then power up the machine. It's a pain, but in the scenario you describe, this is probably the best you can hope for. One final thing: I'm sure you already thought of this, but if the machines are less than a few years old, there may be a BIOS upgrade that will let it boot from USB. Good luck to you!