Speaking of Blender, the latest release (3.3.1) won't launch due to CreateFile2, but a Windows 7 compatible fork of it (https://github.com/nalexandru/BlenderCompat) seems to work just fine.
Edit: Turns out they implemented CreateFile2 and various GetPointer functions in bcompat7 (in the repo posted above, bcompat7 > bcompat7.c line 34), might be worth looking at adding something similar into the kernel globally.