Direct the sound from a software to only 2 chosen speakers (of a 5.1)

[Ben_j]

I have a 5.1 hooked to my media center, and would like to direct my media center app to the 2 front speakers, and iTunes to the 2 rear speakers. Is it possible to do that ?

[Tripredacus]

Post your operating system and sound card. I'm sure those will be factors.