Most drives today that are 3TB+ are 4kn, ie 4k native sectors. And then most are 512e, ie 512k emulated sectors for compatibility. (You can still get 512k sectored drives, but they're usually special order. There's also 528k, 520k and some other formats of sectors used in enterprise storage. In the same vein, you can also buy 4kn drives that fully report 4k sectors with no emulation, again usually special order.)
Most sas drives can be formatted to any sector size very easily using I think it is sg_util in linux (may be something different as I haven't done it myself). And generally this is will work with sas drives that don't otherwise have a lock on changing the sector size. From my reading and some experience, most sata drives cannot change their sector sizes like their sas counterparts--even on the sata versions of sas drives.
I believe the sector changing capability is an artificial limit imposed by manufacturers to make sure sata drives don't replace their more expensive sas counterparts in enterprise storage (as it could save companies literally hundreds of thousands of dollars), but that the best buy easystore drives are a bit of an exception wherein they can be changed to a 4k native mode. I thought it was just the enclosure that was able to do this, so I tried an HGST 10TB drive that I know is 4kn in it and the WD utility did not allow me to change the sector size.
From my research, the My Book series of enclosures uses a encryption which causes a drive that is removed from an enclosure to appear as nothing/raw data when connected directly since the encryption is missing. This isn't a problem if you're just shucking the drive from the enclosure or using the drive exclusively in the enclosure, but becomes a problem when a drive with data is moved in or out of the enclosure. The same limitation doesn't exist on the easystore enclosure so that's why you find them for sale on ebay as they are a fine external enclosure for any drive, and can change certain select drives (who knows which ones?) from 512e to 4kn.