Ok, I just did a quick test of basilisk52-g4.1.win32-git-20190427-3424afcca-xpmod.7z on a usb flash drive with Knoppix 8.2 installed on it using WINE. Serpent/Basilisk ran fine under wine, but there were some "quirks" that showed up that I suspect has more to do with Knoppix's 8.2 GUI interacting with WINE than with either WINE's XP emulation or Serpent/Basilisk running under it.Suspect I need to install and test Serpent/Basilisk on another Linux distro to be sure, but right now I'ld say Serpent/Basilisk runs almost as well under WINE as it does under Windows XP. Haven't see any complaints about missing dll's or anything so far.
Are you serious? You've got people running away on non-xp platforms because of Rust and other Mozilla Browser nonsense. Have you not been paying attention to what's going on?