I have some custom tweaks & settings that get applied and show up fine on the first user account. However when other user accounts are created and those users login, the tweaks and settings are not applied. Now I already know about setting up tweaks and stuff in the Default template which I have applied during CMDLINES. What I would like to do though is have something that detects a new user account and only runs a script the very first time they log in. Any easy way to go about this?

Try to copy your script in Startup folder of Default User.

I havn't tested but it can work. To self-destroy script use "delf /f %0" at the end of your script.

I would like something that can detect when a new account has been created and then have it place something in the startup for that account so that when that person logs in, the script runs once and then goes away. I've seen something before that I think does this called ProfileMonitor.exe that always runs in startup that I believe does this but don't know where to find it or modify it...

do what Sonic said and you will achieve what you are looking for.

what about adding a RunOnce/RunOnceEx entry to the default user profile?

http://support.microsoft.com/kb/314866/