Unpack the npp.5.9.1.bin.7z. Use the ANSI version. It could not run and prompt for missing import functions. It only said IsDebuggerPresent, which is common when compiling with new version of Visual C++.
First, the simplest, is to replace IsDebuggerPresent.
Please refer to https://msfn.org/board/topic/181040-mp4-player-for-windows-95/page/2/, @roytam1 wrote a tool to patch bin. (URL link is updated in quote).
Or you could do it using WinHex.
You should do it for:
Notepad++.exe, SciLexer.dll, plugins\ComparePlugin.dll, plugins\LightExplorer.dll, plugins\NppExec.dll, plugins\NppTextFXA.dll, plugins\PluginManager.dll
(When I started to patch, I didn't patch the plugin files, then Notepad++ will complain about LoadLibrary error for these plugins.)