I'm having the same trouble too. I am running the following in cmdlines.txt [COMMANDS] "REGEDIT /S HKCU.reg" "REGEDIT /S region.reg" Here is the Visual Effects portion of HKCU.reg [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects] "VisualFXSetting"=dword:00000003 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\AnimateMinMax] "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\ComboBoxAnimation] "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\CursorShadow] "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\DragFullWindows] "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\DropShadow] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\FontSmoothing] "DefaultValue"=dword:00000001 "DefaultApplied"=dword:00000001 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\ListBoxSmoothScrolling] "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\ListviewAlphaSelect] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\ListviewShadow] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\ListviewWatermark] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\MenuAnimation] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\SelectionFade] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\TaskbarAnimations] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\TooltipAnimation] "DefaultValue"=dword:00000000 "DefaultApplied"=dword:00000000 [HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects\WebView] "DefaultApplied"=dword:00000000 I want to turn them all off, except font smoothing. The settings just don't seem to have any effect what so ever. I've been trying to get this to work for ages, many virual machines have been killed in the process.... Update: Small start menu icons doesn't apply for me either. Using this code in HKCU.reg "Start_LargeMFUIcons"=dword:00000000 "Start_MinMFU"=dword:0000000c Also I want to turn Hide inactive icons off, can't find the reg key for it though.