It really depends on the motherboard you are using. One motherboard i tried, that claimed it was win98 compatible, and which I think had a VIA chipset, did not run any 6 or 7 series geforce pci-e graphics card I tried on it. Another motherboard, and also the one I am currently using, has an nvidia chipset and works with ALL of the pci-e graphics cards that didn't work in the other motherboard.