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Was the last trace results that high that it might be a reason for crackles in sound? What do you think, NVIDIA GTS450 driver doesn't works with Komplete Audio 6 driver or here might be some issue with other component driver, for example motherboard driver and ka6 driver? I must change some of them to make it work, so what do you advice?

Yes, I have tried all of them but unfortunately with no luck. I have borrowed RME Babyface from our Music Technology Studio. Removed Komplete Audio 6 from USB Port and connected Babyface. I have run same programs — Gom Player, Mozilla Firefox (also plugin_container.exe), Media Player Classic, Cubase 6 AI. RME Interface work very well, with no crackles or pops in sound @ 1024, 512, 256 buffer settings. Here is a log from xperf testing RME Babyface. xperf -i babyface_wo_clicks.etl -a dpcisr > results_dpcisr.txt CPU 0 Usage CPU 1 Usage CPU 2 Usage CPU 3 Usage CPU 4 Usage CPU 5 Usage CPU 6 Usage CPU 7 Usage usec % usec % usec % usec % usec % usec % usec % usec % Module 963793 0.33 2341 0.00 1316073 0.45 0 0.00 687106 0.24 11123628 3.81 1778091 0.61 0 0.00 USBPORT.SYSAndre, I will send you .etl file. I must know is this PC related issue or KA6. Sincerely

KA6 is connected on Intel® ICH10 Family USB Enhanced Host Controller - 3A3A which shares IRQ channel with Intel® ICH10 Family USB Universal Host Controller - 3A34 Here is ASUS Sabertooth X58 IRQ Assignments and video demonstration of my problem that I have recorded on Win7 x86 machine (Now I have x64) http://www.youtube.com/watch?v=oePtCBsHkQE

Hello MagicAndre I have build up custom PC especially for learning electronic music creation. But after setup my rig, there was some annoying pops and crackles in sound. About month I'm trying to figure out how to solve this problem. I've made some research and tested my system with LatencyMon, dpclat, xperf, gpuz, read many topics and articles about DPC issues, but unfortunately most people who are struggling with this problem can't solve it. I have contacted to Native Instruments Support (my sound interface issuer), made some tweaks and advanced configs, but crackles in sound doesn't disappear. Then I've tried to disable devices one by one, and found that without display adapter, it works better but after several minutes, crackles was heard again. NI support team said that it is GPU issuer fault, and I must buy another one or try to change NVIDIA drivers. I have made clean install of updated NVIDIA drivers, several older version drivers but no results. My last chance is to buy another video card and along with item price I don't know will it work better or worse. Shortly, all I have left is some advices by experienced users and I really believe that every task has a solution. Specs: Mobo: ASUS Sabertooth X-58 CPU: Intel Core i7 950 3.06GHz LGA 1366 Video: EVGA GeForce GTS450 1GB SuperClocked Memory: Kingston 6GB (KVR400X64C3A) HDD1: Seagate Barracuda 2TB (ST2000DM001) HDD2: Seagate Barracuda 1TB (ST3100528AS) PSU: Corsair TX650W (CMPSU-650TX) Sound Interface: NI Komplete Audio 6 Actions that I've made: 1. Updated all drivers that i have, including motherboard, graphics card, bios, device firmware and control panel 2. re-arranged system components for fixing IRQ conflicts 3. Disabled CPU TM Function and Intel® SpeedStep ™ Tech in BIOS 4. Disabled Power Savings for CPU, GPU (via EVGA PrecisionX) and USB components 5. Tried all of the usb ports for sound interface 6. Disabled one-by-one each device via Device Manager 7. Performed a Clean Boot 8. Switched from Windows XP SP3 from Windows 7 x86, and now it's Windows 7 x64 (x64 works better among them) 9. Updated .sys files with Windows6.1-KB2529073-x64 but in xperf and LatencyMon it shows older versions of USB drivers. When I go to system32 and watch the versions of files, they're up to date. I don't know why xperf and LatencyMon generates wrong data. 10. Changed Process Buffer and USB Buffer Size from Komplete Audio 6 Control Panel If PC is turned on for several hours (sometimes it takes only several minutes) and I'm running as normal Mozilla Firefox (Youtube or Facebook), Gom Player or DAW after pops and crackles sound little by little slows, it's sounds like robotic scary voice. if i will change USB Buffer from 4ms to 2ms it will sound from robotic sound to normal, with rare occasions of noises. After, it will slow everything in my system, sometimes only way to make it work is reboot os. Mouse/Keyboard freezes, Typing/Deleting strings is slowed in text editor, sometimes i get BSODs, sometimes screen turns off and then renews with notifications from NVIDIA - "Display driver stopped respoding and has recovered". I think issue is GPU related, but not sure. Maybe you can figure out whats the culprit. Your help would be greatly appreciated! Sincerely