This is my motherboard: ASUS M4A89GTD PRO/USB3 AM3 AMD 890GX HDMI SATA 6Gb/s USB 3.0 ATX AMD Motherboard The board has two PCIe 2.0 x 16 slots. The first one (the white-colored panel) is only meant to be used with a single VGA card in the 2nd slot (the blue panel), or in CrossFire. PCIe 2.0 x16_1 slot (gray, at x 8 link) PCIe 2.0 x16_2 slot (blue, single at x 16 or dual at x8 link) Reading through my mobo manual, it told me to install the VGA Switch card in the first slot and to install my single VGA card in the second slot so that I can use the x16 speed, instead of just x8. "For working at x16 speed on the PCIe 2.0 x16_2 slot (blue), it is necessary to install the bundled VGA switch card to the PCIe 2.0 x16_1 slot (gray)." So, that is how I currently have it configured. I have never installed the card in the first slot, nor do I have any previous experience with different PCIe 2.0 slots, so I don't know whether doing so would be a mistake or not. On a side note, the page before it lists the IRQ assignments for the motherboard, and now it makes sense why disabling my JMicron Controller has seemingly solved my problem: ...............................................................|.............C ..................|................D.................| PCIe x16_1...............................................|.................................|...........Shared..............| PCIe x16_2...............................................|..........Shared.............|...................................| Onboard 890GX Video Controller................|..........Shared............|.....................................| Oncip SATA Controller...............................|................................|..............Shared.............| Onboard JMB 36x SATA Controller..............|.................................|...........Shared...............| I have 8 USB ports. Two 2.0 ports on the top front area of the case, four 2.0 ports and two 3.0 ports on the back. My Logitech Webcam is on IRQ 17 (Standard Enhanced PCI to USB Host Controller) However, any port that I connect my mouse and keyboard to use the Standard OpenHCD USB Host Controller, which shares IRQ 18. I'm guessing that the port detects what type of device it is and the appropriate controller takes ownership of it. So, whatever port I connect my Webcam to will always use the Standard Enhanced PCI to USB Host controller, which has no conflict with IRQ 18. To answer your first question, however, I don't believe any of my drives are connected to the JMicron controller. I disabled it last night with no issue and since then have not encountered any system interrupts.