Today I managed to install .NET Framework 4.8 on my VM with Windows Vista Home Basic x64, how did I do it?
First to install it use the method previously used with the .NET Framework 4.6.2 and 4.7.x; nothing more than this time the procedure is longer since when starting any application designed for .NET Framework 4.x in Vista an error dialog appears for lack of instructions in kernel32.dll and ole32.dll respectively.
In HxD edit the clr.dll file that was the library that calls those instructions, replace clr.dll with the edited version and, surprise!
NET Framework 4.8 is compatible with Windows Vista!
Even create a small application with Visual Studio in Windows 7 to see if it worked at all and NET Framework 4.8 works correctly in Vista.
Instructions for installing NET Framework 4.8 on Vista (you need to have a minimum .NET Framework 4.6.1 installed)
2. After finishing the installation, replace clr.dll in "C:\Windows\Microsoft.NET\Framework\v4.0.30319" and "C:\Windows\Microsoft.NET\Framework64\v4.0.30319" with the versions in the zip file
[Tutorial] How to install .Net Framework 4.8 on Windows Vista
in Windows Vista
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with this paint.net 4.0 not start. can you try fix it? please try start paint.net 4.0 - 4.0.3