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I have been spending some time trying to load RunOnce located in HKU\.DEFAULT\Software\Microsoft\Windows\CurrentVersion in an effort to tweak what I thought was the Default User Profile. I was trying to have certain activities occur as each new user gets created. I have been trying to do this logged on as an administrator. No matter what I have tried, nothing has worked. Upon further research, I have discovered that HKU\.DEFAULT, being capitalized is a hive, is located at %SYSTEMROOT%\System32\config\default and that the Default User Profile is NTUSER located at %SystemDrive%\Documents and Settings\Default User and that is in fact the file I should be tweaking. I have learned to tweak it using the REG LOAD and REG UNLOAD approach. Using this approach I have succeeded, however, I remain a little confused.

So here is my question(s) are the two "default profiles" actually related? If so, how? Does one update the other and if so, when? Should I every try and tweak HKU\.DEFAULT?

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