Thanks for the responses. I don't see how my CPU would be an issue, when I was playing a game I did notice it was using about 30% of the host processor, which seems a bit high for an eight core CPU (AMD FX-8350 :/) but it wasn't capping it at 100. Even PCem itself reported about 70-80% CPU and I was still having choppy audio. Maybe I'm not understanding something correctly.
The reason modern hypervisors don't work is because of the experiences UCyborg mentioned. Sometimes, menus wouldn't display, my mouse wouldn't interact with the game properly, etc. I'm still interested in looking around further, but I'd like to stay away from bloating my computer with extra utilities to get things to run. I may try it sometime, but first I'd like to exhaust all possibilities.
Windows 95 should be good enough. AKAIK it's not much different than 98. I was referring to Starsiege: Tribes as being playful albeit a bit slow and choppy. I will report further as I discover more feasible options.
Ultimately, it doesn't look like PC Emulation is anywhere near where WinUAE is with Amiga emulation.