I think, keyword THINK, I might have fixed the problem. Now I don't know if it's a combination or just the driver update that fixed it. I had a Seagate 500gb 5400 rpm drive installed as a secondary drive in my laptop for over a year now. I replaced it with a 750gb 7200rpm drive this evening after ghosting all the data over to it. Now, I booted up and yes I still had spikes shortly after my last post about the chipset, etc. So I jumped on the Intel website in search of newer drivers. It's telling me my chipset drives are the latest released 2009, which I don't fully believe. I updated my Intel 5100 drives about a week ago to a 2009 release because that's all I could find. The online inf identifier informed me there was a newer driver for my wireless adapter as of 07/2010. I installed that driver and checked with the dpc latency checker. I had no red spikes, nothing but green. Also, keep in mind I have my wireless disabled when using audio applications. <UPDATE> While typing this message I seen a couple yellow spikes, and then one red spike. However, it has really improved from previous because I would get them continuously with the wireless disabled. I think the laptop was running for almost 15 minutes straight without any spikes which has never happened before. I'm still in search to see if I can find updated chipset drivers because that could be the missing piece of the puzzle and solve the interrupts for good.