I can confirm it will not harm. Read here: http://www.msfn.org/board/registry-Wow6432Node-after-sp1-t121898.html , in short line: HKLM -> SOFTWARE -> wow6432node -> wow6432node (-> microsoft..windows.. etc ..iexplore.exe)just delete the last wow6432node... It's true that even Windows Live OneCare safety scanner have a huge loop because of this, i'm agree with you that this is pathetic, and untill now i wasn't found what is the cause of this bad entries and how to avoid this, but now i know how to fix this. I can not say vista sucks because of this...it's not perfect, but is much better than xp, xp give me much more headache. My only complaint is the size and inability to remove unused features, this was fixed thanks to Nuhi.After one year with vista ultimate 64 without any blue screen or any major problemm i say: i will never go back to xp, but you are free to make the change if you feel like this. I really can't understand all the negative advertising against vista, at the beginning i was influenced by this, but i say to give a try and i don't regrete this any second. After few tests with vlite i finaly make vista how i wish.