Your Vista x64 comes with a KEY, right? if so, insert it in there and it should be automatically actiavted upon install. However, if ur vista X64 OEM is some form of like Recovery DVD that comes from vendor, then that's a different story because these Recovery DVD reinstall Vista with a bunch of craps. but for now, just vlite it, put in the key, u should be set to go. ps. please speicify what kind of OEM disc, OEM vendor's Recovery DVD or OEM DVD bought from retail like Newegg.