I have run it on 3 monitors (a central 2560 x 1600 display and two 1600 x 1200 displays on the sides, turned up 90 degrees). So far, I've not seen a problem with this particular configuration, but it's a given I don't have the same hardware setup you have, nor do I use Nexus. Notably all my monitors are set to the same scale. As a bit of a stress test just now, since you asked, I opened up quite a few windows, and moved them all around on the 3 monitors without any problems... -Noel